NewsVoir
New Delhi [India], May 23: The latest discoveries outlined in the new report were released today
Cancer Prevention Research
Daily consumption of walnuts might enhance markers of systemic inflammation and lower the risk of colon cancer. Colon cancer is among the most prevalent types globally, making up approximately 10% of all cancer cases.2 The compound Urolithin A (UA), which arises from the metabolism of plant-based polyphenols called ellagitannins present in walnuts, is believed to play a role in these health benefits.
Scientists from the University of Connecticut investigated the effect of eating 56 grams of walnuts every day on various health markers in 39 adults aged between 50 and 65 years old over a period of three weeks before they underwent a standard colonoscopy procedure. The research built upon earlier work conducted by Dr. Masako Nakanishi, also part of the Rosenberg laboratory team, who initially documented how walnut intake influences colon cancer risk factors.
In this new study, investigators discovered that individuals following a walnut-rich dietary regimen exhibited elevated amounts of urinary urolithin A (UA), accompanied by reduced concentrations of multiple inflammatory substances circulating within their bloodstream.
Moreover, the research revealed alterations in colon polyps which might eventually demonstrate potential benefits in thwarting certain types of cancer progression. Previous studies have explored urolithins due to their anti-inflammatory characteristics and possible roles in cancer prevention. The investigation suggests that elevated concentrations of urinary urolithin A (UA) could account for these modifications seen in polyp tissue samples, following only brief walnut consumption periods.
Dr. Daniel W. Rosenberg, who holds the position of HealthNet Chair in Cancer Biology and works as an investigator at the Center for Molecular Oncology at the University of Connecticut School of Medicine, has spent over ten years researching the properties of walnuts and their potential anti-inflammatory effects. According to Rosenberg, “Walnuts serve as an excellent source of health-boosting compounds known as ellagitannins. Once these substances are metabolized into urolithin A by our intestinal bacteria, they can help decrease inflammation and might play a role in lowering the likelihood of developing colon cancer.”
In addition to their ellagitannin levels, walnuts are recognized for their nutritional profile. They stand out as the sole nut offering an exceptional amount of omega-3 ALA (2.5g per 28g), a compound studied for its benefits to brain function, cardiovascular well-being, and beyond. Furthermore, walnuts supply 4 grams of plant-derived protein alongside various additional nutrients in each serving size.
This research contributes to the increasing body of evidence highlighting walnuts as a functional food offering advantages that extend beyond fundamental nutrition. Walnuts have the distinctive capability to generate urolithin A —a substance associated with decreased inflammation and possible defense against colon cancer— making them particularly pertinent now, considering the rising number of Indians encountering digestive health issues due to contemporary eating habits and lifestyles. Consuming a small portion of walnuts each day is an easy yet impactful routine that can enhance gut health and promote general well-being,” asserts Naaznin Husein, who is part of the Indian Dietetic Association.
Enjoying the health advantages of walnuts can be achieved simply by adding a portion to your dishes and treats. Here are some recipes to help you include California walnuts in your diet:
* During breakfast, consider trying this
tropical mango smoothie bowl
* Snack on these
California walnut ladoos
or
smoked spiced California walnuts
* Prepare a large portion of these
California walnut kebabs
for dinner
Further investigation is necessary since this study was comparatively limited in size and duration. It remains uncertain if the noted impacts of walnut consumption would continue over an extended timeframe or within a broader participant group. Moreover, the research did not employ a randomized controlled design.
To learn more about how walnuts contribute to cancer prevention, enhance gut health, or for creative recipe suggestions, kindly visit.
californiawalnuts.in
The California Walnut Commission (CWC), which stands for over 3,700 Californian walnut producers and about 70 processors, operates primarily within multigeneration farming families’ orchards. These California walnuts, renowned for their superior nutrition and quality, are distributed globally throughout the entire year; nearly all—more than 99 percent—of U.S.-grown walnuts come from this state. Founded in 1987, the CWC works towards expanding both domestic and international markets for walnuts and also backs health studies related to walnut consumption.
References:
1. The World Health Organization. Colorectal Cancer. Retrieved from the World Health Organization website on May 2, 2025; last updated July 11, 2023.
https://www.who.int/news-room/fact-sheets/detail/colorectal-cancer
2. Moussa MR, Fan N, Birk J, et al. The systemic inflammation along with the inflammatory setting within the colonic environment shows improvement due to Urolithin A administration. Cancer Prev Res (Phila). 2025;18(4):235-50.
3. Nakanishi M, Chen Y, Qendro V, et al. The Impact of Consuming Walnuts on Colon Tumor Development and Alterations in Microbiome Composition. Cancer Prevention Research. August 2016;9(8):692-703. doi: 10.1158/1940-6207.CAPR-16-0026
4. Fan N, Fusco JL, Rosenberg DW. The antioxidant and anti-inflammatory effects of walnut components: Emphasis on tailored cancer prevention and the role of the microbiome. Antioxidants. 2023;12(5):982.
5. Mandalari G, Gervasi T, Rosenberg DW, Lapsley KG, Baer DJ. Impact of Nuts on Digestive Health. Nutrients. 2023;15(7):1733.
6. Sala-Vila A, Fleming J, Kris-Etherton PM, Ros E. The effect of alpha-linolenic acid, a plant-based omega-3 fatty acid, on cardiovascular health and cognitive function [published online February 16, 2022]. Advances in Nutrition.
doi.org/10.1093/advances/nmac016.
7. U.S. Department of Agriculture, Agricultural Research Service. FoodData Central, released in 2019.
Fdc.nal.usda.gov.
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